any of various leguminous plants of the genera Astragalus and Oxytropis, of the southwestern U.S. and Mexico, causing locoism in sheep, horses, etc.

1875–80, Americanism; loco + weed1

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World English Dictionary
locoweed (ˈləʊkəʊˌwiːd)
any of several perennial leguminous plants of the genera Oxytropis and Astragalus of W North America that cause loco disease in horses, cattle, and sheep

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Example sentences
Animals are allowed to graze in heavy stands of plants that are highly poisonous, such as locoweed or larkspur.
The comparative pathology of locoweed poisoning in livestock, wildlife and rodents.
Native legumes such as purple prairie clover, locoweed, and prairie turnip are abundant in the nitrogen-poor loess soils.
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