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mono-

1.
a combining form meaning “alone,” “single,” “one” (monogamy); specialized in some scientific terms to denote a monomolecular thickness (monolayer) and adapted in chemistry to apply to compounds containing one atom of a particular element (monohydrate).
Also, especially before a vowel, mon-.
Origin
< Greek, combining form of mónos alone
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Based on the Random House Dictionary, © Random House, Inc. 2014.
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British Dictionary definitions for mono-

mono-

combining form
1.
one; single: monochrome, monorail
2.
indicating that a chemical compound contains a single specified atom or group: monoxide
Word Origin
from Greek monos
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition
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Word Origin and History for mono-

word-forming element meaning "one, alone; containing one (atom, etc.)," from Greek mono-, comb. form of monos "single, alone," from PIE root *men- "small, isolated" (cf. Greek manos "rare, sparse," Armenian manr "thin, slender, small," and perhaps English minnow).

Online Etymology Dictionary, © 2010 Douglas Harper
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mono- in Medicine

mono- or mon-
pref.

  1. One; single; alone: monomorphic.

  2. Monomolecular; monatomic: monolayer.

  3. Containing one atom, molecule, or group: monomer.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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mono- in Science
mono-  
A prefix that means "one, only, single," as in monochromatic, having only one color. It is often found in chemical names where it means "containing just one" of the specified atom or group, as in carbon monoxide, which is carbon attached to a single oxygen atom.
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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