in spite of; without being opposed or prevented by: Notwithstanding a brilliant defense, he was found guilty. She went to the game anyway, doctor's orders notwithstanding.
in spite of the fact that; although: It was the same material, notwithstanding the texture seemed different.
nevertheless; anyway; yet: We were invited notwithstanding.
Origin: 1350–1400;Middle English (preposition, adv., and conjunction); see not, withstand, -ing2
Synonyms 1. Notwithstanding, despite, in spite of imply that something is true even though there are obstacles or opposing conditions. The three expressions may be used practically interchangeably. Notwithstanding suggests, however, a hindrance of some kind: Notwithstanding the long delay, I shall still go.Despite indicates that there is an active opposition: Despite procrastination and disorganization, they finished the project.In spite of implies meeting strong opposing forces or circumstances that must be taken into account: She succeeded in spite of many discouragements.