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osteopetrosis

[os-tee-oh-pi-troh-sis] /ˌɒs ti oʊ pɪˈtroʊ sɪs/
noun, Pathology
1.
any of several hereditary diseases characterized by increased bone density.
Origin
1925-1930
1925-30; osteo- + Greek petrō-, variant stem of petroûn to turn to stone (derivative of pétra stone) + -sis -sis; see -osis
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Based on the Random House Dictionary, © Random House, Inc. 2014.
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osteopetrosis in Medicine

osteopetrosis os·te·o·pe·tro·sis (ŏs'tē-ō-pě-trō'sĭs)
n.
An inherited disorder in which bone and cartilage, especially in long bones, becomes dense and hardened to an extent that marrow is obliterated, and anemia, spleen and liver enlargement, blindness, and progressive deafness occur; it begins in infancy and sometimes results in early death. Also called Albers-Schönberg disease, marble bone disease, marble bones.


os'te·o·pe·trot'ic (-trŏt'ĭk) adj.
The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Encyclopedia Article for osteopetrosis

marble bone disease

rare hereditary congenital disorder in which the bones become extremely dense, hard, and brittle. The disease progresses as long as bone growth continues; the marrow cavities become filled with compact bone, and severe anemia results. In marble bone disease, bone-resorbing cells called osteoclasts are either reduced in number or are ineffective. Fractures are frequent; deafness and loss of vision may occur because cranial nerves become compressed by the narrowing of their passageways as bone is deposited in the skull. Severe cases may be fatal; individuals with mild cases of the disorder may have a normal life expectancy. Treatment may include gamma interferon, a protein that delays progression of the disease; bone marrow transplantation; or calcitriol, a vitamin D compound that stimulates osteoclasts to dissolve and absorb bone.

Learn more about marble bone disease with a free trial on Britannica.com
Encyclopedia Britannica, 2008. Encyclopedia Britannica Online.
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