probenecid

[proh-ben-uh-sid]
noun Pharmacology.
a white, crystalline, water-insoluble powder, C 1 3 H 1 9 NO 4 S, used chiefly in the treatment of gout.

Origin:
1945–50; pro(pyl) + ben(zen)e + (a)cid

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American Heritage
Medical Dictionary

probenecid pro·ben·e·cid (prō-běn'ĭ-sĭd)
n.
A uricosuric drug derived from benzoic acid and used chiefly in the treatment of gout.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Encyclopedia Britannica
Encyclopedia

probenecid

drug used in the treatment of chronic gout, a disorder that is characterized by recurrent acute attacks of inflammation in one or more joints of the extremities. Probenecid inhibits the transport of most organic acids in the renal tubules of the kidneys. It was used in medicine originally to prolong the action of the antibiotic penicillin by preventing its loss in the urine. In large doses, however, probenecid enhances the excretion of uric acid, the compound that accumulates in and about the joints in persons with gout. Continued administration of the drug in gouty arthritis shrinks solid uric acid deposits in the joints and reduces swelling in enlarged joints, thus restoring their mobility.

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Encyclopedia Britannica, 2008. Encyclopedia Britannica Online.
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Example sentences
Probenecid is taken two to three times a day, and sulfinpyrazone begins at twice a day and increases to three or four times daily.
Daily use of allopurinol or probenecid decrease uric acid levels in your blood.
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