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substrate sub·strate (sŭb'strāt')
The material or substance on which an enzyme acts.
A surface on which an organism grows or is attached.
The body or base layer of an integrated circuit, onto which other layers are deposited to form the circuit. The substrate is usually Silicon, though Sapphire is used for certain applications, particularly military, where radiation resistance is important. The substrate is originally part of the wafer from which the die is cut. It is used as the electrical ground for the circuit.