verb (used with object)
to pinch and pull with a jerk and twist: to tweak someone's ear; to tweak someone's nose.
to pull or pinch the nose of, especially gently: He tweaked the baby on greeting.
to make a minor adjustment to: to tweak a computer program.
an act or instance of tweaking; a sharp, twisting pull or jerk.

1595–1605; akin to twitch Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
tweak (twiːk)
1.  to twist, jerk, or pinch with a sharp or sudden movement: to tweak someone's nose
2.  slang motor racing to tune (a car or engine) for peak performance
3.  informal to make a minor alteration
4.  an instance of tweaking
5.  informal a minor alteration
[Old English twiccian; related to Old High German zwecchōn; see twitch]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

probably from O.E. twiccian "to pluck," of obscure origin; perhaps related to twitch. Meaning "to make fine adjustments" is attested from 1966.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
The experiment revealed that the genetic tweaking, indeed, rendered the mice
  resistant to weight gain.
So let's see how the theory needs tweaking to include the true power of the
  galaxies ie invisible electricity.
Maybe with a little tweaking it could give evolution a run for its money.
By tweaking these factors, they should be able to increase the amount of light
  that the cells absorb.
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