the localized death of living cells (as from infection or the interruption of blood supply) [syn: necrosis]
3.
an instance in which you are caused to lose your prestige or self-respect; "he had to undergo one humiliation after another" [syn: humiliation]
4.
(Christianity) the act of mortifying the lusts of the flesh by self-denial and privation (especially by bodily pain or discomfort inflicted on yourself)
Cha*grin"\, n. [F., fr. chagrin shagreen, a particular kind of rough and grained leather; also a rough fishskin used for graters and files; hence (Fig.), a gnawing, corroding grief. See Shagreen.] Vexation; mortification. I must own that I felt rather vexation and chagrin than hope and satisfaction. --Richard Porson. Hear me, and touch Belinda with chagrin. --Pope. Syn: Vexation; mortification; peevishness; fretfulness; disgust; disquiet. Usage: Chagrin, Vexation, Mortification. These words agree in the general sense of pain produced by untoward circumstances. Vexation is a feeling of disquietude or irritating uneasiness from numerous causes, such as losses, disappointments, etc. Mortification is a stronger word, and denotes that keen sense of pain which results from wounded pride or humiliating occurrences. Chagrin is literally the cutting pain produced by the friction of Shagreen leather; in its figurative sense, it varies in meaning, denoting in its lower degrees simply a state of vexation, and its higher degrees the keenest sense of mortification. "Vexation arises chiefly from our wishes and views being crossed: mortification, from our self-importance being hurt; chagrin, from a mixture of the two." --Crabb.
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