[hahy-per-splee-niz-uhm, -splen-iz-]
noun Pathology.
an abnormal condition characterized by an enlarged spleen that prematurely destroys red blood cells or platelets.
Also called hypersplenia [hahy-per-splee-nee-uh] .

1910–15; hyper- + splen- + -ism

hypersplenic, adjective
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American Heritage
Medical Dictionary

hypersplenism hy·per·splen·ism (hī'pər-splěn'ĭz'əm, -splē'nĭz'əm)
A condition in which the hemolytic action of the spleen is greatly increased.

The American Heritage® Stedman's Medical Dictionary
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Example sentences
Thrombocytopenia due to platelet destruction and hypersplenism.
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