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verb (used with object), irritated, irritating.
to excite to impatience or anger; annoy.
Physiology, Biology. to excite (a living system) to some characteristic action or function.
Pathology. to bring (a body part) to an abnormally excited or sensitive condition.
verb (used without object), irritated, irritating.
to cause irritation or become irritated.

1525–35; < Latin irrītātus, past participle of irrītāre to arouse to anger, excite, aggravate, equivalent to irritā- v. stem + -tus past participle suffix

irritator, noun

aggravate, annoy, intensify, irritate, worsen (see synonym study at aggravate).

1. vex, chafe, fret, gall; nettle, ruffle, pique; incense, enrage, infuriate, inflame. Irritate, exasperate, provoke mean to annoy or stir to anger. To irritate is to excite to impatience or angry feeling, often of no great depth or duration: to irritate by refusing to explain an action. To exasperate is to irritate to a point where self-control is threatened or lost: to exasperate by continual delays and excuses. To provoke is to stir to a sudden, strong feeling of resentful anger as by unwarrantable acts or wanton annoyance: to tease and provoke an animal until it attacks.
Dictionary.com Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
irritate (ˈɪrɪˌteɪt)
1.  to annoy or anger (someone)
2.  (tr) biology to stimulate (an organism or part) to respond in a characteristic manner
3.  (tr) pathol to cause (a bodily organ or part) to become excessively stimulated, resulting in inflammation, tenderness, etc
[C16: from Latin irrītāre to provoke, exasperate]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
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Word Origin & History

1530s, from L. irritatus, from pp. stem of irritare "excite, provoke." An earlier verb form was irrite (mid-15c.), from O.Fr. irriter.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
Your letter must be long enough to contain real substance but not so long that
  it becomes irritating.
It was a little irritating to see my first post mocked with a pointless and
  flip answer.
Ozone reacts with compounds in skin oils, resulting in some potentially
  irritating chemicals.
In addition, even irritating family members often provide support and warmth
  you cannot afford to give up.
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