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late 14c., "mortifying the flesh, suppression of bodily desires," from Late Latin mortificationem (nominative mortificatio) "a killing, putting to death," from past participle stem of mortificare (see mortify). Sense of "feeling of humiliation" first recorded 1640s.
mortification mor·ti·fi·ca·tion (môr'tə-fĭ-kā'shən)
Death or decay of one part of a living body; gangrene; necrosis.