verb (used with object)
to cause to be puzzled or bewildered over what is not understood or certain; confuse mentally: Her strange response perplexed me.
to make complicated or confused, as a matter or question.
to hamper with complications, confusion, or uncertainty.

1585–95; back formation from perplexed

perplexer, noun
perplexingly, adverb
unperplexing, adjective

1. mystify, confound. 2. tangle, snarl. 3. vex, annoy, bother. Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
perplex (pəˈplɛks)
1.  to puzzle; bewilder; confuse
2.  to complicate: to perplex an issue
[C15: from obsolete perplex (adj) intricate, from Latin perplexus entangled, from per- (thoroughly) + plectere to entwine]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Example sentences
It's also perplexing why features acquired for life in water so many millions
  of years ago should have been retained, he added.
Another perplexing question is what selective pressures led long-necked
  stegosaurs to evolve.
And perhaps it's even more perplexing that the recipient of all this largesse
  somehow managed to piddle it all away.
However, files are categorized by an obscure terminology that can make choosing
  one perplexing.
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