pox

[poks]
noun Pathology.
1.
a disease characterized by multiple skin pustules, as smallpox.
3.
Also called soil rot. Plant Pathology. a disease of sweet potatoes, characterized by numerous pitlike lesions on the roots, caused by a fungus, Streptomyces ipomoea.
4.
(used interjectionally to express distaste, rejection, aversion, etc.): A pox on you and your bright ideas!

Origin:
1540–50 (earlier as surname); spelling variant of pocks, plural of pock

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World English Dictionary
pox (pɒks)
 
n
1.  any disease characterized by the formation of pustules on the skin that often leave pockmarks when healed
2.  the pox an informal name for syphilis
3.  archaic (interjection) a pox on someone an expression of intense disgust or aversion for someone
 
[C15: changed from pocks, plural of pock]

Collins English Dictionary - Complete & Unabridged 10th Edition
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Etymonline
Word Origin & History

pox
1476, spelling alteration of pockes, pl. of pocke (see pock). Especially (after 1503) of syphilis.
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

pox (pŏks)
n.

  1. A disease such as chickenpox or smallpox, characterized by purulent skin eruptions that may leave pockmarks.

  2. Syphilis.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Example sentences for pox
He went on to develop vaccines against small pox, cholera, and swine erysipelas.
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